Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Susumu Eguchi Mitsuhisa Takatsuki Masaaki Hidaka Akihiko Soyama Izumi Muraoka Tetsuo Tomonaga Isao Shimokawa Takashi Kanematsu
- چاپ و سال / کشور: 2010
Description
Background A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors. Aims This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient. Methods Of 119 living donor liver transplants, ten pairs were adult-to-pediatric combinations. Senescence marker protein-30 (SMP-30), which is a protein that is remarkably reduced upon aging, was used as a senescence marker. Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation (LDLT). Re-expression of SMP-30 was investigated in a biopsied adult liver (n = 6) that had been transplanted in a pediatric recipient. Results A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy. Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver. Conclusion An adult grafted liver does not appear to rejuvenate in a pediatric recipient.
Dig Dis Sci (2011) 56:1542–1547 DOI 10.1007/s10620-010-1445-5 Received: 10 July 2010 / Accepted: 19 September 2010 / Published online: 9 October 2010
