Clinical Significance of Discordant Positive Hepatitis C Virus Transcription–Mediated Amplification Following End of Treatment Response
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Anisha Thadani Jennifer Harley Jonah Rubin Edward Lebovics
- چاپ و سال / کشور: 2011
Description
Background Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. Methods We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA? result to assess the clinical significance of a positive TMA result after a PCR negative EOT response or sustained viral response (SVR). Patients were divided into Group 1: PCR-/TMA? after EOT response but during 24 week follow-up (n = 4); and Group 2: PCR-/TMA? after SVR (n = 11). Results All Group 1 patients achieved SVR. No Group 2 patients became PCR positive or had a rise in ALT. The TMA subsequently became negative in 6/7 patients with follow-up evaluation. Conclusions A discordant positive TMA post-EOT response or SVR did not seem to be clinically significant. This finding supports the possibility that patients with SVR have an acquired immune surveillance that prevents lowlevel viremia from progressing to clinical relapse
Dig Dis Sci DOI 10.1007/s10620-011-1820-x Received: 17 March 2011 / Accepted: 30 June 2011
