Levels of awakening salivary CgA in response to stress in healthy subjects
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Rei Den Masahiro Toda Masako Ohira Kanehisa Morimoto
- چاپ و سال / کشور: 2009
Description
Objects To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. Methods The study cohort comprised 40 healthy male university students (age range 19–22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening). Results The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the ‘‘severe depression’’ subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p\0.05). Conclusions Our findings indicate that depression may influence secretions of salivary CgA via chronic stressrelated attenuation of the sympathetic–adrenomedullary system activity.
Environ Health Prev Med (2011) 16:155–157 DOI 10.1007/s12199-010-0179-5 Received: 24 December 2009 / Accepted: 20 August 2010 / Published online: 23 September 2010
