Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Toyohiro Kato Hiroaki Kawaguchi Noriaki Miyoshi Kohji Aoyama Masaharu Komatsu Masahisa Horiuchi Hiroki Yoshida Toru Takeuchi
- چاپ و سال / کشور: 2010
Description
Objectives We investigated whether habitual exercise (HE) (treadmill running) suppresses development of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Methods Male Fischer 344 rats were divided into six groups: group I, saline treatment (12 weeks = initiation period) and non-HE; group II, Fe-NTA treatment (12 weeks) and non-HE; group III, saline treatment and short-term (12 weeks) HE; group IV, Fe-NTA treatment and short-term HE; group V, saline treatment and long-term(40 weeks) HE; and group VI, Fe-NTA treatment and long-term HE. Saline treatment groups did not develop RCC, therefore we investigated the effects of HE among Fe-NTA treatment groups. Results Gross nodules (diagnosed as RCC), RCC represented by microcarcinomas (Mcs), karyomegalic cells (KCs), and degenerative tubules (DTs) were seen in rats treated with Fe-NTA. The number of Mcs, KCs, and DTs were increased in the short-term HE group when compared with those in the non-HE group, but were decreased in the long-term HE group when compared with those in the short-term HE group. Conclusions Short-term (initiation period) HE promoted renal carcinogenesis induced by Fe-NTA; however, longterm HE after the initiation period suppressed the promoted carcinogenesis.
Environ Health Prev Med (2011) 16:232–238 DOI 10.1007/s12199-010-0191-9 Received: 29 September 2010 / Accepted: 27 October 2010 / Published online: 25 November 2010
