Current concepts of organ preservation in head and neck cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : C.-J. Wang · R. Knecht
- چاپ و سال / کشور: 2011
Description
The treatment of laryngeal and hypopharyngel cancer nowadays is not limited by surgical resection. There are many interdisciplinary approaches which we can oVer these patients in our clinics. These include radiotherapy, chemotherapy, biologicals and surgery. The combination of radiotherapy, chemotherapy, biologicals and surgery techniques more and more allows us to perform organ and function preservation in a former often mutilating and function destroying treatment. Since the early 1990s, evidence from large randomized trials has shown that organ preservation studies using sequential and concomitant radio-chemotherapy do not compromise survival when compared with surgery followed by radiotherapy. However, using these therapies side eVects have to be taken into consideration and not organ preservation but function preservation is the treatment goal. The current most common treatment options are shown here in this review. For future treatment protocols there is an urgent need to reWne the deWnition of a functional organ, to deWne quality of life endpoints and to reWne the recommendations for evaluating treatment response.
Eur Arch Otorhinolaryngol (2011) 268:481–487 Received: 19 August 2010 / Accepted: 8 October 2010 / Published online: 25 November 2010 © Springer-Verlag 2010
