Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Carolin M. Grimminger · Peter V. Danenberg
- چاپ و سال / کشور: 2011
Description
Oropharyngeal squamous cell carcinomas (OSCC) constitute about 5% of all cancers in the western world and the incidence and mortality rates of this tumor have shown little improvement over the last 30 years. Molecular targeted therapy, a promising strategy for the treatment of OSCC and other cancers, requires the understanding of speciWc molecular events of carcinogenesis and the diVerent pathological, partly interrelated pathways. Extended knowledge of the prognostic or predictive value of molecular biomarkers in oropharyngeal cancer is necessary to allow a better characterization and classiWcation of the tumor, improve the appraisal of clinical outcome and help to specify individual multimodal therapy with increased eYciency. This work aVords an updated summary regarding recent data about tissue biomarkers in patients with OSCC, based on the six essential hallmarks of cancer described by Hanahan and Weinberg (Cell 100(1):57–70, 2000) providing the characterization of a malignant cell.
Eur Arch Otorhinolaryngol (2011) 268:5–16, Received: 23 June 2010 / Accepted: 12 August 2010 / Published online: 9 September 2010 © Springer-Verlag 2010
