Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dimitrios Koutsimpelas · Jürgen Brieger · Ulf Heinrich · Michael Torzewski · Clemens Sommer · Wolf J. Mann
- چاپ و سال / کشور: 2011
Description
Malignant triton tumour (MTT) is a rare, highly malignant neoplasm, characterized by a mixture of cells with nerve sheath and skeletal muscle diVerentiation. Cytogenetic analyses of this neoplasm are rare to date and none comparative genomic hybridisation (CGH) analysis has been published. In the present study we report about the genomic imbalances of a MMT analysed by CGH, in a 39- year-old male patient without neuroWbromatosis. We observed the ampliWcations at chromosomal location 1p, 6p, 16p, 16q, 17p, 17q, 19p, 19q, 20p, and 22q. Comparing our results with those of previous studies, we found evidence for recurrent genomic aberrations at the chromosomes 1, 16, 17, 19, and 22 suggesting the involvement of several oncogenes in the genesis of MTT.
Eur Arch Otorhinolaryngol (2011) 268:1391–1396,Received: 8 September 2010 / Accepted: 24 May 2011 / Published online: 5 June 2011 © Springer-Verlag 2011
