High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menie`re’s disease: a case series
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Franziska Lezius Christine Adrion Ulrich Mansmann Klaus Jahn Michael Strupp
- چاپ و سال / کشور: 2011
Description
The objective of this study was to evaluate the clinical benefit and the side effects of high dosages of betahistine dihydrochloride (288–480 mg/day) in patients with severe Menie`re’s disease (MD). In this case series 11 patients with MD who had not responded sufficiently to a dosage of 144 mg/day of betahistine dihydrochloride were treated on an individual basis with daily dosages between 288 and 480 mg of betahistine dihydrochloride. The number of attacks per month and the side effects were monitored. Non-parametric tests were used for statistical analysis. As a result, the frequency and the severity of vertigo were significantly reduced in all patients. The side effects were mild, self-limiting, and did not require any change in the treatment strategy. Despite the considerable limitations of an observational study—in particular in MD—high dosages of betahistine dihydrochloride between 288 and 480 mg/day seem to be effective in patients who do not sufficiently respond to lower dosages. Moreover, such dosages are well tolerated
Eur Arch Otorhinolaryngol (2011) 268:1237–1240,Received: 20 February 2011 / Accepted: 11 May 2011 / Published online: 29 May 2011 Springer-Verlag 2011
