Inhibition of Wbroblast growth factor receptor 1: inXuence on tympanic membrane wound healing in rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Holger Kaftan · Lars Reuther · Bنrbel Miehe · Werner Hosemann · Achim Beule
- چاپ و سال / کشور: 2011
Description
An animal model of chronic tympanic membrane (TM) perforation is needed for experiments on supporting healing of TM perforations. The basic Wbroblast growth factor is important in TM wound healing. The object of this study was to investigate the eYcacy of Wbroblast growth factor receptor 1 (FGFR1) inhibition to arrest wound healing of experimental TM perforation. Bilateral instrumental myringotomies were performed in 12 rats. A speciWc inhibitor of the FGFR1 tyrosine kinase (SU5402) was applied to the left TM (2 mg/ml) and to the right TM (10 mg/ml) of each animal daily for 12 consecutive days. Thereafter, TMs were observed weekly for a total of 30 days. TM healing was delayed in a dose-dependent manner. We observed diVerences in the histologic parameters between both groups. SU 5402 is a strong inhibitor of TM healing but seems not to be suitable to create a chronic TM perforation in rat.
Eur Arch Otorhinolaryngol, Received: 6 January 2011 / Accepted: 29 April 2011 © Springer-Verlag 2011
