Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Pasquale Capaccio Lorenzo Pignataro Lorenzo M. Gaini Paolo E. Sigismund Cristina Novembrino Rachele De Giuseppe Valentina Uva Armando
- چاپ و سال / کشور: 2011
Description
An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis
Eur Arch Otorhinolaryngol DOI 10.1007/s00405-011-1671-2, Received: 8 February 2011 / Accepted: 8 June 2011
