The effect of a 4-week treatment with reboxetine on metabolic parameters of depressed inpatients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Georgios Paslakis Maria Gilles Florian Lederbogen Claudia Schilling Barbara Scharnholz Michael Deuschle
- چاپ و سال / کشور: 2011
Description
In the present study, we examined several metabolic parameters in a group of 19 acutely depressed inpatients with major depression (DSM-IV) at baseline and investigated their development after 4 weeks of antidepressant treatment with reboxetine (8–12 mg per day). We performed oral glucose tolerance tests and additionally assessed free saliva cortisol and post-dexamethasone cortisol levels, as well as whole cholesterol, HDL- and LDLcholesterol, triglycerides, free fatty acids, waist and hip circumference, heart rate, systolic and diastolic blood pressure. Furthermore, we evaluated the incidence of a metabolic syndrome and investigated the metabolic changes in depressed patients with and without a metabolic syndrome. We found 42.1% of patients to fulfil the criteria for a metabolic syndrome. Overall, reboxetine was well tolerated with essentially no side effects during the observation period. A 4-week treatment with reboxetine showed a beneficial effect on several metabolic parameters that was independent from treatment outcome and could therefore theoretically be attributed to the pharmacological profile of the drug. Due to the preliminary character of the present investigation, no conclusions about the clinical efficacy of reboxetine can be drawn
Eur Arch Psychiatry Clin Neurosci (2011) 261:173–177 DOI 10.1007/s00406-010-0164-4, Received: 12 January 2010 / Accepted: 19 October 2010 / Published online: 30 October 2010
