Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Xuan Wang • Yue-Hua Li • Ming-Hua Li • Jing Lu • Jun-Gong Zhao • Xiao-Jiang Sun • Bin Zhang • Jian-Lin Ye
- چاپ و سال / کشور: 2011
Description
In recent studies, the glutamate (Glu) level has been quantified using the modified STEAM sequence on 3T MRI. We enrolled 15 healthy volunteers and a group of 51 patients who experienced stroke for the first time and had a good prognosis. The patients with infarction were divided into three groups according to their scores by using the DSM-IV diagnostic criteria for major depressive disorder and the 17-item Hamilton Depression Rating Scale (HDRS). We studied the association between post-stroke depression and 1H-MRS measurements in unaffected frontal lobes. Single-voxel proton magnetic resonance spectroscopy (1H-MRS) was performed to assess N-acetylaspartate/ creatine (NAA)/Cr, (Glu)/Cr, choline (Cho)/Cr, and myoinositol (mI)/Cr ratios in stroke patients. The 11 patients (21.5%) who met the criteria for depression and 9 patients (17.6%) who had a high score for HDRS, ([14) but were not depressed, had a significantly higher Glu/Cr ratio than patients who scored B14 on HDRS and control groups (p\0.001). No differences were found in NAA/Cr, Cho/Cr, or mI/Cr between the groups after stroke. These findings suggest that post-stroke depression is accompanied by changes in glutamate levels in the frontal lobe.
Eur Arch Psychiatry Clin Neurosci DOI 10.1007/s00406-011-0209-3,
