Expression profile of Toll-like receptors in monocytes of peripheral blood from osteoarthritic patients undergoing arthroplasty
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Zi Ji Zhang Yan Kang Zhi Qi Zhang Yang Chun Zhang Wei Ming Liao Pu Yi Sheng
- چاپ و سال / کشور: 2011
Description
To investigate the difference in the expression of TLRs in monocytes from patients with/without implants. Blood samples from 21 osteoarthritic patients undergoing joint replacement (11 cases) or arthroscopy (10 cases) were tested. Blood samples were obtained within 24 h before surgery and the third postoperative day to measure cellassociated TLRs by FCM. The results showed that in the absence of clinical infection, implantation of joint prosthesis seems to be associated with a significant decrease in circulating TLR2- and TLR7-positive cells, whereas the decrease in TLR4- and TLR9-positive cells was not statistically significant. A small intervention in the form of knee arthroscopy was without effect. TLRs seem to be affected by the implantation of joint prosthesis, perhaps by migration to and entrapment in peri-implant tissues. Due to their role in innate and adaptive immunity, TLRs may have consequences for the postoperative inflammation and infection.
Eur J Orthop Surg Traumatol DOI 10.1007/s00590-011-0819-5 Received: 13 April 2011 / Accepted: 10 May 2011
