The effect of vitamin A on renal damage following acute pyelonephritis in children
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Parviz Ayazi & Seyed Alireza Moshiri & Abolfazl Mahyar & Mona Moradi
- چاپ و سال / کشور: 2011
Description
Animal studies suggest that administration of vitamin A to rats with experimental urinary tract infection decreases the frequency of renal scars (Kavukçu et al., BJU Int 83(9):1055–1059, 1999). The aim of this study was to determine the effect of vitamin A on the rate of permanent renal damage in children with acute pyelonephritis. Fifty children, median age of 24 months (range 2–144), with first-time pyelonephritis verified by an uptake defect on acute dimercaptosuccinic acid (DMSA) scan were included in the study and randomly allocated to the case or control groups. All were given intravenous ceftriaxone for 10 days followed by oral cephalexin for 3 months. Cases in addition were given a single intramuscular dose of vitamin A, 25,000 U for infants below 1 year of age and 50,000 U for older children. At the repeat DMSA scan after 3 months, five of 25 cases (20%) and 17 of 25 controls (68%) had abnormal findings (p=0.001). In conclusion, administration of vitamin A was associated with a significantly lower rate of permanent renal damage.
Eur J Pediatr (2011) 170:347–350 DOI 10.1007/s00431-010-1297-1 Received: 18 July 2010 / Accepted: 7 September 2010 / Published online: 18 September 2010
