Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Clemens Schiestl & Kathrin Neuhaus & Silke Zoller & Ulrike Subotic & Ishilde Forster-Kuebler & Rike Michels & Christian Balmer & Lisa Weibel
- چاپ و سال / کشور: 2011
Description
Beta-blockers are a highly promising treatment modality for complicated infantile hemangiomas (IH). However, data on propranolol as first-line treatment, objective outcome measures and impact on hemodynamics in young infants is limited. We retrospectively evaluated a homogenous group of infants with proliferating complicated IH treated with propranolol (2 mg/kg/day). Outcome was assessed by blinded evaluation of clinical photographs by visual analogue scale (VAS), ultrasound examination and ophthalmological review (if appropriate). Tolerance and hemodynamic variables were recorded over time, including a 2-day in-patient observation at the initiation of therapy. Twenty-five infants (median age 3.6 (1.5–9.1) months) were included in the study. The median follow-up-time was 14 (9– 20) months and 14 patients completed treatment at a median age of 14.3 (11.4–22.1) months, after a duration of 10.5 (7.5– 16) months. In all patients, there was significant fading of colour (with a VAS of -9 (-6 to -9) after 7 months) and significant decrease in size of the IH (with a VAS of -8 (-3 to -10) after 7 months). Median thickness of the lesions assessed by ultrasound at baseline and after 1 month was 14 (7–28) mm and 10 (5–23) mm, respectively (p<0.01). In children with periocular involvement, astigmatism and amblyopia resolved rapidly within 8 weeks. The overall tolerance of propranolol was good, and no relevant hemodynamic changes were noted. Conclusion: Our report supports the excellent effect and good tolerance of this novel therapy, and we propose the use of propranolol as first-line treatment for IH.
Eur J Pediatr (2011) 170:493–501 DOI 10.1007/s00431-010-1324-2, Received: 21 June 2010 / Revised: 26 September 2010 / Accepted: 28 September 2010 / Published online: 9 October 2010
