Combination therapy for life-threatening pulmonary hypertension in a premature infant: first report on bosentan use
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maurizio Radicioni & Alessia Bruni & Piergiorgio Camerini
- چاپ و سال / کشور: 2011
Description
Premature infants with preterm premature rupture of membranes (PPROM) are at high risk of severe respiratory failure because of lung hypodysplasia associated with persistent pulmonary hypertension of the newborn (PPHN). We describe the clinical course of a 28-week gestation infant with PPROM from the 20th week and prolonged oligohydramnios before delivery, who developed refractory hypoxia treated with oral bosentan as adjunct therapy to inhaled nitric oxide (iNO) and oral sildenafil. Conclusion Our experience suggests that bosentan can be used in the premature infant with PPHN after PPROM. To the best of our knowledge, this is the first report of bosentan treatment in a premature infant.
Eur J Pediatr (2011) 170:1075–1078 DOI 10.1007/s00431-011-1422-9 Received: 20 December 2010 / Accepted: 7 February 2011 / Published online: 8 March 2011
