Risk assessment and management in hand and facial tissue transplantation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : J. H. Barker F. Allen M. Cunningham P. S. Basappa O. Wiggins J. C. Banis Jr. R. R. Alloway W. E. Steve J. M. Frank
- چاپ و سال / کشور: 2011
Description
new treatments, risk data must be derived from early reports of the few cases done to date combined with extrapolations from other procedures with similar risks. This manuscript summarizes data from both sources including eight separate studies that measure the real and perceived risks associated with hand and facial tissue transplantation. Methods Real Risks: Several large clinical studies describing risk data from kidney transplant recipients (10- years experience) and risk data from 49 human hand transplants in 33 recipients ([10 years experience) were reviewed. Perceived Risks: Over 500 subjects with different life experiences (facially disfigured, amputees, laryngectomees, kidney transplant recipients, transplant and reconstructive surgeons, and controls) were surveyed using a standardized and validated risk assessment instrument. Results Real Risks: Contrary to earlier estimates the risks of acute rejection are higher (80–85%) while the risks of chronic rejection (\5%) and other complications are lower than previously reported. Perceived Risks: Despite different life experiences, those questioned would accept similar amounts of risk to receive different types of transplant procedures (hand, foot, face, larynx, and kidney) but all would accept the most risk for a facial tissue transplant. Kidney transplant recipients, who live with the risks of immunosuppression, would accept the most risk while facially disfigured individuals and reconstructive surgeons,
Eur J Trauma Emerg Surg DOI 10.1007/s00068-011-0131-4 Received: 17 February 2011 / Accepted: 16 June 2011
