Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Argyro Xyda & Ulrike Haberland & Ernst Klotz & Hans Christoph Bock & Klaus Jung & Michael Knauth & Ramona Schramm & Marios Nikos Psychogios & Gunter E
- چاپ و سال / کشور: 2011
Description
Objectives Validation of the feasibility and efficacy of volume perfusion computed tomography (VPCT) in the preoperative assessment of cerebral gliomas by applying a 128-slice CT covering the entire tumour. Methods Forty-six patients (25 men, 21 women; mean age 52.8 years) with cerebral gliomas were evaluated with VPCT. Two readers independently evaluated VPCT data, drawing volumes of interest (VOIs) around the tumour according to maximum intensity projection volumes, which were mapped automatically onto the cerebral blood volume (CBV), flow (CBF) and permeability (Ktrans) perfusion datasets. As control, a second VOI was placed in the contralateral healthy cortex. Correlation among perfusion parameters, tumour grade, hemisphere and VOIs was assessed. The diagnostic power of perfusion parameters was analysed by receiver operating characteristics curve analyses. Results VPCT was feasible in the assessment of the entire tumour extent. Mean values of Ktrans, CBV, CBF in highgrade gliomas were significantly higher compared with low-grade (p<0.01). Ktrans demonstrated the highest diagnostic (97% sensitivity), positive (100%) and negative (94%) prognostic values. Conclusions VPCT was feasible in all subjects. All areas of different perfusion characteristics are depicted and quantified in colour-coded 3D maps. The derived parameters correlate well with tumour histopathology, differentiating low- from high-grade gliomas.
Eur Radiol (2011) 21:1811–1819 DOI 10.1007/s00330-011-2150-2 Received: 12 October 2010 / Revised: 15 January 2011 / Accepted: 18 February 2011 / Published online: 15 May 2011
