Prediction of bone loss in elderly female subjects by MR perfusion imaging and spectroscopy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : James F. Griffith & David K. W. Yeung & Jason Chi Shun Leung & Timothy C. Y. Kwok & Ping C. Leung
- چاپ و سال / کشور: 2011
Description
Objective To determine whether MR perfusion indices or marrow fat content at baseline can predict areal bone mineral density (BMDa) loss. Methods Repeat dual x-ray absorptiometry (DXA) of the hip was performed in female subjects at 2 years (n=52) and 4 years (n=45) following baseline MR perfusion imaging and spectroscopy of the hip. Results Percentage reduction in femoral neck BMDa at 4 years post-baseline was greater in subjects with below median acetabulum enhancement slope (Eslope) (−5.6±1.2 Vs −1.1±1.2 (mean ± standard error) p=0.014) or muscle maximum enhancement (Emax) (−5.7±1.2 Vs −0.23±1.2, p=0.009) after adjusting for baseline co-variables. Baseline MR parameters correlated with reduction in BMDa at 4 years (acetabulum Eslope r=0.517, p=0.0003; muscle Emax r=0.306, p=0.043) as well as traditionally applied clinical risk factors. Acetabulum Eslope, femoral neck Emax and marrow fat content at baseline had sensitivities of 89%, 81% and 72% respectively at distinguishing between fast (>1%/annum) (n=18) and slow (<1%/annum) (n=27) BMD losers. Conclusion Elderly female subjects with reduced perfusion indices at baseline had increased femoral neck bone loss at 4 years. Selected perfusion indices and marrow fat content have a moderate to high sensitivity in discriminating between fast and slow bone losers.
Eur Radiol (2011) 21:1160–1169 DOI 10.1007/s00330-010-2054-6 Received: 19 August 2010 / Revised: 12 December 2010 / Accepted: 15 December 2010 / Published online: 13 January 2011
