Sonoelastographic lesion stiffness: preoperative predictor of the presence of an invasive focus in nonpalpable DCIS diagnosed at US-guided needle biopsy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nariya Cho &Woo Kyung Moon & Jung Min Chang & Ann Yi & Hye Ryoung Koo & Jeong-Seon Park & In Ae Park
- چاپ و سال / کشور: 2011
Description
Objectives To retrospectively evaluate whether sonoelastographic evaluation could help predict the presence of an invasive focus in nonpalpable DCIS diagnosed at USguided needle biopsy. Methods One hundred and three consecutive nonpalpable DCIS lesions diagnosed at US-guided needle biopsy were analyzed. To identify the preoperative factors associated with upgrade to invasive cancers on surgical histology, lesion size, B-mode US findings, elasticity score, biopsy variables, and histological variables were analyzed using univariate and multivariate logistic regression. Interobserver agreement for the elasticity score was evaluated using the multi-rater κ statistics. Results The overall upgrade rate was 23% (24 of 103). Elasticity score was found to be the only independent predictor of invasion. The upgrade rates according to the median elasticity score was 6.7% (1 of 15) for a score of 1, 20.6% (13 of 63) for a score of 2, and 40.0% (10 of 25) for a score of 3 (Odds ratio [OR]=1; OR=4.19, P=0.207; OR= 12.32, P=0.039, respectively). No association was found between other factors and the upgrade rate. The overall interobserver agreement for the elasticity score was moderate (κ=0.587; P<.001). Conclusions Sonoelastographic lesion stiffness is an independent preoperative predictor of invasion in some patients with nonpalpable DCIS at US-guided needle biopsy.
Eur Radiol (2011) 21:1618–1627 DOI 10.1007/s00330-011-2103-9 Received: 12 November 2010 / Revised: 4 February 2011 / Accepted: 9 February 2011 / Published online: 13 March 2011
