Additional benefit of 18F-fluorodeoxyglucose integrated positron emission tomography/computed tomography in the staging of oesophageal cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : R. S. Gillies & M. R. Middleton & N. D. Maynard & K. M. Bradley & F. V. Gleeson
- چاپ و سال / کشور: 2010
Description
tomography (FDG PET) has been shown to improve the accuracy of staging in oesophageal cancer. We assessed the benefit of PET/CT over conventional staging and determined if tumour histology had any significant impact on PET/CT findings. Methods A retrospective cohort study, reviewing the results from 200 consecutive patients considered suitable for radical treatment, undergoing routine PET/CT staging comparing the results from CT and endoscopic ultrasound, as well as multi-disciplinary team records. Adenocarcinoma and squamous cell carcinoma were compared for maximum Standardised Uptake Value (SUVmax), involvement of local lymph nodes and distant metastases. Results PET/CT provided additional information in 37 patients (18.5%) and directly altered management in 34 (17%): 22 (11%) were upstaged; 15 (7.5%) were downstaged, 12 of whom (6%) received radical treatment. There were 11 false negatives (5.5%) and 1 false positive (0.5%). SUVmax was significantly lower for adenocarcinoma than squamous cell carcinoma (median 9.1 versus 13.5, p=0.003). Conclusions Staging with PET/CT offers additional benefit over conventional imaging and should form part of routine staging for oesophageal cancer. Adenocarcinoma and squamous cell carcinoma display significantly different FDG-avidity.
Eur Radiol (2011) 21:274–280 DOI 10.1007/s00330-010-1943-z Received: 29 March 2010 / Revised: 7 July 2010 / Accepted: 9 July 2010 / Published online: 4 September 2010
