4D-MR flow analysis in patients after repair for tetralogy ot
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : J. Geiger &M. Markl & B. Jung & J. Grohmann & B. Stiller & M. Langer & R. Arnold
- چاپ و سال / کشور: 2011
Description
Objectives Comprehensive analysis of haemodynamics by 3D flow visualisation and retrospective flow quantification in patients after repair of tetralogy of Fallot (TOF). Methods Time-resolved flow-sensitive 4D MRI (spatial resolution ~ 2.5 mm, temporal resolution = 38.4 ms) was acquired in ten patients after repair of TOF and in four healthy controls. Data analysis included the evaluation of haemodynamics in the aorta, the pulmonary trunk (TP) and left (lPA) and right (rPA) pulmonary arteries by 3D blood flow visualisation using particle traces, and quantitativemeasurements of flow velocity. Results 3D visualisation of whole heart haemodynamics provided a comprehensive overview on flow pattern changes in TOF patients, mainly alterations in flow velocity, retrograde flow and pathological vortices. There was consistently higher blood flow in the rPA of the patients (rPA/lPA flow ratio: 2.6±2.5 vs. 1.1±0.1 in controls). Systolic peak velocity in the TP was higher in patients (1.9 m/s±0.7 m/s) than controls (0.9 m/s±0.1 m/s). Conclusions 4D flow-sensitive MRI permits the comprehensive evaluation of blood flow characteristics in patients after repair of TOF. Altered flow patterns for different surgical techniques in the small patient cohort may indicate its value for patient monitoring and potentially identifying optimal surgical strategies.
Eur Radiol (2011) 21:1651–1657 DOI 10.1007/s00330-011-2108-4 Received: 11 January 2011 / Revised: 27 January 2011 / Accepted: 4 February 2011 / Published online: 29 March 2011
