Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : A. Müller & S. Remmele & I. Wenningmann & H. Clusmann & F. Trنber & S. Flacke & R. Kِnig & J. Gieseke &W. A. Willinek & H. H. Schild & P. Mürtz
- چاپ و سال / کشور: 2010
Description
Objective To investigate the response in R2* relaxation rate of human intracranial tumours during hyperoxic and hypercapnic respiratory challenges. Methods In seven patients with different intracranial tumours, cerebral R2* changes during carbogen and CO2/ air inhalation were monitored at 3 T using a dynamic multigradient-echo sequence of high temporal and spatial resolution. The R2* time series of each voxel was tested for significant change. Regions of interest were analysed with respect to response amplitude and velocity. Results The tumours showed heterogeneous R2* responses with large interindividual variability. In the ‘contrastenhancing’ area of five patients and in the ‘non-tumoral’ tissue most voxels showed a decrease in R2* for carbogen. For the ‘contrast-enhancing’ area of two patients hardly any responses were found. In areas of ‘necrosis’ and perifocal ‘oedema’ typically voxels with R2* increase and no response were found for both gases. For tissue responding to CO2/air, the R2* changes were of the same order of magnitude as those for carbogen. The response kinetic was generally attenuated in tumoral tissue. Conclusion The spatially resolved determination of R2* changes reveals the individual heterogeneous response characteristic of intracranial human tumours during hyperoxic and hypercapnic respiratory challenges.
Eur Radiol (2011) 21:786–798 DOI 10.1007/s00330-010-1948-7 Received: 6 July 2010 / Accepted: 8 August 2010 / Published online: 22 September 2010
