Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson’s disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Adriane Grِger & Grzegorz Chadzynski & Jana Godau & Daniela Berg & Uwe Klose
- چاپ و سال / کشور: 2011
Description
Objectives To investigate the substantia nigra in patients with Parkinson’s disease three-dimensional magnetic resonance spectroscopic imaging with high spatial resolution at 3 Tesla was performed. Regional variations of spectroscopic data between the rostral and caudal regions of the substantia nigra as well as the midbrain tegmentum areas were evaluated in healthy controls and patients with Parkinson’s disease. Methods Nine patients with Parkinson’s disease and eight age- and gender-matched healthy controls were included in this study. Data were acquired by using three-dimensional magnetic resonance spectroscopic imaging measurements. The ratios between rostral and caudal voxels of the substantia nigra as well as the midbrain tegmentum areas were calculated for the main-metabolites N-acetyl aspartate, creatine, choline, and myo-inositol. Additionally, the metabolite/ creatine ratios were calculated. Results In all subjects spectra of acceptable quality could be obtained with a nominal voxel size of 0.252 ml. The calculated rostral-to-caudal ratios of the metabolites as well as of the metabolite/creatine ratios showed with exception of choline/creatine ratio significant differences between healthy controls and patients with Parkinson’s disease. Conclusions The findings from this study indicate that regional variations in N-acetyl aspartate/creatine ratios in the regions of the substantia nigra may differentiate patients with Parkinson’s disease and healthy controls.
Eur Radiol (2011) 21:1962–1969 DOI 10.1007/s00330-011-2123-5 Received: 8 December 2010 / Revised: 4 February 2011 / Accepted: 24 February 2011 / Published online: 12 April 2011
