Early postoperative MRI overestimates residual tumour after resection of gliomas with no or minimal enhancement
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sinan M. K. Belhawi & Friso W. A. Hoefnagels & Johannes C. Baaijen & Esther Sanchez Aliaga & Jaap C. Reijneveld & Jan J. Heimans & Frederik Barkhof &
- چاپ و سال / کشور: 2011
Description
Background Standards for residual tumour measurement after resection of gliomas with no or minimal enhancement have not yet been established. In this study residual volumes on early and late postoperative T2-/FLAIRweighted MRI are compared. Methods A retrospective cohort included 58 consecutive glioma patients with no or minimal preoperative gadolinium enhancement. Inclusion criteria were first-time resection between 2007 and 2009 with a T2-/FLAIR-based target volume and availability of preoperative, early (<48 h) and late (1–7 months) postoperative MRI. The volumes of nonenhancing T2/FLAIR tissue and diffusion restriction areas were measured. Results Residual tumour volumes were 22% smaller on late postoperative compared with early postoperative T2- weighted MRI and 49% smaller for FLAIR-weighted imaging. Postoperative restricted diffusion volume correlated with the difference between early and late postoperative FLAIR volumes and with the difference between T2 and FLAIR volumes on early postoperative MRI. Conclusion We observed a systematic and substantial overestimation of residual non-enhancing volume on MRI within 48 h of resection compared with months postoperatively, in particular for FLAIR imaging. Resection-induced ischaemia contributes to this overestimation, as may other operative effects. This indicates that early postoperative MRI is less reliable to determine the extent of non-enhancing residual glioma and restricted diffusion volumes are imperative.
Eur Radiol (2011) 21:1526–1534 DOI 10.1007/s00330-011-2081-y Received: 27 September 2010 / Revised: 16 December 2010 / Accepted: 10 January 2011 / Published online: 18 February 2011
