Heart and liver T2* assessment for iron overload using different software programs
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Juliano L. Fernandes & Erika Fontana Sampaio & Monica Verissimo & Fabricio B. Pereira & Jose Alvaro da Silva & Gabriel S. de Figueiredo & Jose M. Kal
- چاپ و سال / کشور: 2011
Description
Objectives To assess the level of agreement and interchangeability among different software programs for calculation of T2* values for iron overload. Methods T2* images were analysed in 60 patients with thalassaemia major using the truncation method in three software programs. Levels of agreement were assessed using Pearson correlation and Bland-Altman plots. Categorical classification for levels of iron concentration by each software program was also compared. Results For the heart, all correlation coefficients were significant among the software programs (P<0.001 for all coefficients). The mean differences and 95% limits of agreement were 0.2 (-4.73 to 5.0); 0.1 (-4.0 to 3.9); and -0.1 (-4.3 to 4.8). For the liver all correlations were also significant with P<0.001. Bland-Altman plots showed differences of -0.02 (-0.7 to 0.6); 0.01 (-0.4 to 0.4); and -0.02 (-0.6 to 0.6). There were no significant differences in clinical classification among the software programs. Conclusions All tools used in this study provided very good agreement among heart and liver T2* values. The results indicate that interpretation of T2* data is interchangeable with any of the software programs tested. Key Points & Magnetic resonance imaging in iron overload assessment has become an essential tool. & Post processing options to establish T2* values have not been compared. & No differences were found on T2* of the liver or heart using 3 different techniques. & Availability of these methods should allow more widespread interpretation of iron overload by MRI.
DOI 10.1007/s00330-011-2208-1 Received: 1 April 2011 / Revised: 22 May 2011 / Accepted: 17 June 2011
