Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mayumi Takeuchi & Kenji Matsuzaki & Masafumi Harada
- چاپ و سال / کشور: 2011
Description
Objective To retrospectively evaluate the clinical significance of N-acetyl resonances at 2 ppm in in-vivo proton magnetic resonance (MR) spectroscopy for distinguishing mucinous and non-mucinous tumours in patients with ovarian masses. Methods MR spectroscopy was performed in patients with pathologically diagnosed ovarian tumours at 3T-MR imaging. Single-voxel MR spectroscopy data were collected from a single square volume of interest that encompassed the ovarian masses. The metabolite resonance peak areas at 2 ppm were quantified relative to unsuppressed water using a software package (LCModel). Results A total of 32 ovarian lesions in 32 patients were evaluated in this study. High metabolite peak at 2 ppm was observed in all nine mucinous tumours (9.71 +/- 7.46 mM), whereas low peak was observed in 14 of 23 non-mucinous tumours (3.12 +/- 1.42 mM) (p<0.001). Using a cut off value of 4.45 mM for mucinous tumours had a sensitivity of 89%, specificity of 86%, PPVof 80%, and NPVof 92%. Conclusion Proton MR spectroscopy with quantitative evaluation of the metabolite at 2 ppm concentration, which may suggest the presence of mucinous material containing N-acetyl mucinous compounds, can provide helpful information in distinguishing mucinous and nonmucinous ovarian tumours. Key Points , MR spectroscopy helps distinguish mucinous from nonmucinous ovarian tumours. , High N-acetyl resonance at 2 ppm is observed in ovarian mucinous tumours. , Thus MR spectroscopy could improve management of these patients
Eur Radiol DOI 10.1007/s00330-011-2215-2 Received: 23 April 2011 / Revised: 8 June 2011 / Accepted: 2 July 2011
