Macromolecule content influences proton diffusibility in gliomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Einar Goebell & Jens Fiehler & Susanne Siemonsen & Ole Vaeterlein & Oliver Heese & Christian Hagel & Xiao-Qi Ding & Jan-Hendrik Buhk &Michael Groth &
- چاپ و سال / کشور: 2011
Description
Objectives Different compositions of the extra cellular matrix with changing concentrations of more or less hydrophilic components like proteins may have a major influence on the diffusion phenomena found in gliomas. Methods 24 patients (14 male / 10 female) with histologically confirmed non necrotic glioma underwent preoperative MRI, including magnetisation transfer (MTR), triple echo T2 weighted (T2W) and diffusion weighted (DWI) sequences. Apparent diffusion coefficient (ADC), quantitative T2 and MTR maps were calculated and regions of interest (ROIs) were placed in the tumour centre (TU) and in the contralateral hemisphere (NWM). Informed consent was obtained. The study was approved by the local ethic comity. Results Mean values evaluated in the NWM / TU were (± standard deviation); ADC: 0.78 (±0.08)×10-3 mm2/s / 1.32 (±0.27)×10-3 mm2/s, T2: 101.66 (±12.00) ms / 252.11 (±104.53) ms, MTR: 0.52 (±0.01) / 0.40 (±0.04). The mean value of each parameter correlated highly significant with the others (p<0.01). Conclusion Our results suggest that macromolecules binding protons in their vicinity are a major determinant of proton diffusivity in brain tumours in addition to other factors such as mechanical barriers like membranes or the size of the extra-cellular space.
Eur Radiol DOI 10.1007/s00330-011-2206-3 Received: 28 March 2011 / Revised: 29 May 2011 / Accepted: 14 June 2011
