Quantitative analysis and prediction of regional lymph node status in rectal cancer based on computed tomography imaging
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Chunyan Cui & Hongmin Cai & Lizhi Liu & Liren Li & Haiying Tian & Li Li
- چاپ و سال / کشور: 2011
Description
Objectives To quantitatively evaluate regional lymph nodes in rectal cancer patients by using an automated, computeraided approach, and to assess the accuracy of this approach in differentiating benign and malignant lymph nodes. Methods Patients (228) with newly diagnosed rectal cancer, confirmed by biopsy, underwent enhanced computed tomography (CT). Patients were assigned to the benign node or malignant node group according to histopathological analysis of node samples. All CT-detected lymph nodes were segmented using the edge detection method, and seven quantitative parameters of each node were measured. To increase the prediction accuracy, a hierarchical model combining the merits of the support and relevance vector machines was proposed to achieve higher performance. Results Of the 220 lymph nodes evaluated, 125 were positive and 95 were negative for metastases. Fractal dimension obtained by the Minkowski box-counting approach was higher in malignant nodes than in benign nodes, and there was a significant difference in heterogeneity between metastatic and non-metastatic lymph nodes. The overall performance of the proposed model is shown to have accuracy as high as 88% using morphological characterisation of lymph nodes. Conclusions Computer-aided quantitative analysis can improve the prediction of node status in rectal cancer
Eur Radiol DOI 10.1007/s00330-011-2182-7 Received: 24 December 2010 / Revised: 24 April 2011 / Accepted: 27 April 2011
