Clinical significance of primary lesion FDG uptake for choice between oesophagectomy and endoscopic submucosal dissection for resectable oesophageal squamous cell carcinomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Masatoyo Nakajo & Masayuki Nakajo & Atsushi Tani & Yoriko Kajiya & Shunji Shimaoka & Akio Matsuda & Tatsuyuki Nioh & Tohru Nihara & Toyokuni Suenaga
- چاپ و سال / کشور: 2011
Description
Objectives To correlate primary oesophageal squamous cell carcinoma (SCC) 18F-fluoro-deoxyglucose (FDG) uptake with pathological factors and examine its significance regarding choice of therapy. Methods We retrospectively examined the factors affecting visible and non-visible FDG uptake in 37 primary lesions in 32 oesophageal SCC patients who underwent PET/CT before oesophagectomy or endoscopic submucosal dissection (ESD). We divided the lesions into pathological depth invasion .sm2 oesophagectomy (n=18) and .sm1 ESD (n=19) indicated groups and compared the diagnostic accuracy of FDG-PET with that of endoscopic ultrasound (EUS) performed for 23 superficial lesions to discriminate between these groups. Results There were 17 visible and 20 non-visible lesions. The lesion visibility was significantly higher in the larger (.40 mm), non-flat type, more deeply invaded, positive vascular invasion (P<0.001 each), positive nodal metastasis (P=0.04) and higher Glut-1 score (P=0.005) tumour groups. When the visible and non-visible lesions indicated a need for oesophagectomy and ESD respectively, the sensitivity, specificity and accuracy of oesophagectomy were 94% (17/18), 100% (19/19) and 97% (36/37) and those of EUS were 75% (3/4), 79% (15/19) and 78% (18/23) respectively.
Eur Radiol DOI 10.1007/s00330-011-2196-1 Received: 4 February 2011 / Revised: 21 April 2011 / Accepted: 13 May 2011
