The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yuan CHEN , MD, PhD, Qi TIAN, BS
- چاپ و سال / کشور: 2011
Description
Protein kinase C epsilon (PKC ه) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ه in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ه functions in vivo, and PKC ه has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ه on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ه could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ه signal pathway in the developing brain.
Front. Med. 2011, 5(1): 70–76 DOI 10.1007/s11684-011-0119-9 Higher Education Press and Springer-Verlag Berlin Heidelberg 2011
