Survival and prognosticators of gastric cancer that recurs after adjuvant chemotherapy with S-1
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Toru Aoyama Takaki Yoshikawa Takafumi Watanabe Tsutomu Hayashi Takashi Ogata Haruhiko Cho Akira Tsuburaya
- چاپ و سال / کشور: 2011
Description
Background Some patients experience a recurrence of cancer even after curative D2 gastrectomy followed by adjuvant S-1 chemotherapy. The objective of this retrospective study was to clarify the survival and prognosticators in these patients. Methods The study selected patients who underwent curative D2 surgery, were diagnosed with stage II, IIIA, or IIIB cancer, received adjuvant S-1 for more than 4 weeks, and experienced recurrence confirmed by an imaging study. Results A total of 34 patients were evaluated. The median overall survival (OS) was significantly longer in the 26 patients who received palliative chemotherapy than that in the 8 who did not (8.5 vs. 2.5 months, P = 0.002). Only 1 patient received S-1, 21 received taxane-containing regimens, and 4 received irinotecan plus cisplatin as the firstline chemotherapy. Univariate and multivariate analyses showed that the histological type was only independent significant prognosticator. Conclusions These results suggested that the survival did not reach the level expected for first-line chemotherapy. The histological type was a significant prognosticator in patients who experienced recurrence after adjuvant S-1 therapy and thereafter received palliative chemotherapy
Gastric Cancer (2011) 14:150–154 DOI 10.1007/s10120-011-0020-x Received: 10 August 2010 / Accepted: 1 December 2010 / Published online: 16 February 2011
