Value of sentinel lymph node mapping using a blue dye-only method in gastric cancer: a single-center experience from North-East Hungary
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dezs}o To´th Zsolt Kincses Ja´nos Plo´sz Miklo´s To¨ro¨k Ilona Kova´cs Csongor Kiss La´szlo´ Damjanovich
- چاپ و سال / کشور: 2011
Description
Background Forty percent of patients with gastric cancer have unnecessarily extended lymph node dissections with higher rates of morbidity and mortality than those in nonextended procedures. Successful sentinel lymph node (SLN) mapping may help to reduce the number of extended lymphadenectomies. Methods SLN mapping was investigated by a blue dyeonly method in patients with gastric cancer. The first cohort of patients (n = 16) were marked submucosally by an endoscopist and in the second cohort of patients (n = 23) a subserosal injection was performed by the surgeon. Results Thirty-nine patients, all Caucasians, underwent gastric resection or total gastrectomy with SLN biopsy using patent blue-dye mapping and modified D2 lymphadenectomy. The mapping procedure and the lymphadenectomy were supervised by the same surgeon. A total of 770 lymph nodes were removed and examined. The mean number of blue nodes was 4.3 per patient. In 22/23 cases at least one SLN showed tumor involvement. The sensitivity of SLN mapping was 95.7%, the false-negative rate was 4.3%, and the specificity was 100%. The negative predictive value was 93.8% and the positive predictive value was 100%. In cases of T1 and T2 tumors the sensitivity was 100%. We found the two marking methods (submucosal vs. subserosal) to be equivalent and there was no side-effect of the blue-dye mapping. Conclusions Our results suggest that SLN mapping with blue dye alone represents a safe procedure that seems to be adaptable for non-obese patients undergoing open surgery for gastric cancer in the Eastern European region. The procedure has high sensitivity and specificity, especially in cases of T1 and T2 tumors
Gastric Cancer DOI 10.1007/s10120-011-0048-y Received: 20 January 2011 / Accepted: 29 March 2011
