p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hye-Rim Song Sun-Seog Kweon Hee Nam Kim Jin-Mei Piao Woo-Jun Yun Jin-Su Choi Jun-Eul Hwang Ju-Young Yoon Hyeong-Rok Kim Young-Kyu P
- چاپ و سال / کشور: 2011
Description
Background The common p53 codon 72 polymorphism has been investigated as a risk factor for cancer in different populations; however, the results have been inconsistent. This study investigated the risk of developing gastric or colorectal cancer associated with the p53 codon 72 polymorphism in a Korean population. Methods We conducted a large-scale case–control study that included 2,213 gastric cancer patients; 1,829 colorectal cancer patients; and 1,700 healthy controls. Genotyping was performed with real-time polymerase chain reaction (PCR), using a TaqMan single-nucleotide polymorphism (SNP) genotyping assay. Results The frequencies of Arg/Arg, Arg/Pro, and Pro/ Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively. The Pro/Pro genotype was associated with an increased risk of gastric [age- and sex-adjusted odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.01–1.56, P = 0.04] and colorectal cancer (OR = 1.36, 95% CI = 1.07–1.72, P = 0.01). There were no significant interactions between the p53 codon 72 polymorphism and smoking or drinking. Conclusions Our results suggest that the Pro/Pro genotype is associated with modest increases in the risks of gastric cancer and colorectal cancer in a Korean population
Gastric Cancer DOI 10.1007/s10120-011-0034-4 Received: 2 November 2010 / Accepted: 13 February 2011
