Clinical validity of endoscopic submucosal dissection for submucosal invasive gastric cancer: a single-center study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yoji Sanomura Shiro Oka Shinji Tanaka Ikue Noda Makoto Higashiyama Hiroki Imagawa Takayoshi Shishido Shigeto Yoshida Toru Hiyama K
- چاپ و سال / کشور: 2011
Description
Background The 2010 Japanese Gastric Cancer Association guidelines for the treatment of submucosal invasive gastric cancer (SM-GC) specify size 30 mm or less, differentiated- dominant histology, lack of vessel involvement, and submucosal invasion of less than 500 lm (SM1) as expanded criteria for curative endoscopic resection. Our purpose in this study was to confirm the validity of the expanded indications for curative endoscopic submucosal dissection (ESD) of SM-GC. Methods The study subjects were 173 patients with SMGC resected by ESD at Hiroshima University Hospital between April 2002 and September 2010, including 99 patients for whom 3-plus years’ follow-up information was available. Post-ESD outcomes were compared between cases of SM1-GC that met the expanded ESD criteria, those that did not, and SM2-GC cases. Results Complete resection was achieved for 93.2% of the SM1-GCs that met the expanded criteria. There was neither metastasis to lymph nodes or other organs nor local recurrence among the SM1-GCs. Disease-specific survival did not differ significantly between patients that were simply followed up after ESD and those that were treated by additional surgical resection. Conclusions Our outcome data support the clinical validity of ESD without additional surgical resection for SM1-GCs that meet the expanded criteria.
Gastric Cancer DOI 10.1007/s10120-011-0076-7 Received: 19 April 2011 / Accepted: 26 June 2011
