Increase in preoperative serum reactive oxygen metabolite levels indicates nodal extension in patients with clinical stage I lung adenocarcinoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Takuma Tsukioka, MD, PhD Noritoshi Nishiyama, MD, PhD Takashi Iwata, MD, PhD · Koshi Nagano, MD Shinjiro Mizuguchi, MD, PhD · Keiko Tei, MD Kenich
- چاپ و سال / کشور: 2010
Description
Purpose. Reactive oxygen species contribute to various features of malignant tumors, including carcinogenesis, aberrant growth, metastasis, and angiogenesis. Investigation of serum oxidative stress levels may predict the tumor’s condition, including malignant and metastatic potential. Methods. We recruited 46 patients (27 men, 19 women; median age 70 years) with clinical stage I lung adenocarcinoma who had undergone pulmonary resection with mediastinal lymph node dissection. Preoperative serum reactive oxygen metabolite (ROM) levels were measured as an indicator of oxidative stress. Results. The serum ROM level was signifi cantly correlated with the increase in tumor size (P = 0.018) and pathological nodal extension (P = 0.005). Multivariate analysis revealed that pathological nodal extension was signifi cantly correlated with the increase in serum ROM level (P = 0.027). The prognostic cutoff value was determined according to receiver operating characteristic curve analysis for patients with and those without nodal extension; the cutoff value was determined to be 318 Carratelli units (U.CARR).Conclusion. The fi ndings of our study revealed that patients with clinical stage I lung adenocarcinoma and a serum ROM level above 318 U.CARR were likely to develop nodal extension. The fi nding of a signifi cant correlation between serum ROM level and nodal extension may help in the development of new treatment strategies.
Gen Thorac Cardiovasc Surg (2011) 59:335–340 DOI 10.1007/s11748-010-0739-z Received: 15 September 2010 / Accepted: 1 November 2010
