Abnormalities of renal function in the elderly
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Patricia F. Abreu, Luiz R. Ramos & Ricardo Sesso
- چاپ و سال / کشور: 1999
Description
Objective: To investigate the glomerular and proximal tubular renal function and the prevalence of urinary abnormalities in the elderly. Design: Cross-sectional study. Setting: General community in the city of Sمo Paulo. Participants: A population-based sample of 200 elderly subjects was randomly selected. Of these, 81 subjects (45 females and 36 males; mean SD age: 73.7 6 years) accepted to undergo laboratory examination and were included in the study. Main outcome measures: 24-h creatinine clearance (CCr), microalbuminuria, urinary retinol-binding protein (urRBP), leucocyturia, hematuria and total proteinuria. Results: CCr was lower than 80 ml/min/1.73m2 in 68% of the subjects. The median (range) CCr was 65 ml/min/1.73m2 (21–112) in males and 77 ml/min/1.73m2 (27–107) in females (p = 0.14). No individual had serum creatinine greater than 1.5 mg/dl. urRBP determination was normal in 79 of 81 subjects. The prevalence of microalbuminuria (>20 mg/ml) was 31% (n = 25, 19 men and 6 women).These individuals presented higher mean systolic blood pressure (147 20 vs. 135 22 mmHg, p = 0.02) and mean serum creatinine (1.13 0.20 vs. 0.96 0.20 mg/dl, p < 0.01) than those without microalbuminuria. The prevalence of leukocyturia (>10,000/mm3), hematuria (>10,000/mm3) and total proteinuria (>0.3mg/dl) was 19%, 28% and 5% in males and 33%, 27% and 4% in females. Conclusions: Glomerular dysfunction and urinary abnormalities are frequent features in the elderly, however, proximal tubular dysfunction is uncommon in this population. Introduction
Geriatric Nephrology and Urology 9: 141–145, 1999. © 1999 Kluwer Academic Publishers. Printed in the Netherlands. Accepted 31 March 1999
