Nandrolone decanoate is a good alternative for the treatment of anemia in elderly male patients on hemodialysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Antonio Gasc´on1, Ju´an J. Belvis1, Francisca Berisa1, Emilia Iglesias1, Vicente Estopiٌ´an1 & Jos´e L. Teruel2
- چاپ و سال / کشور: 1999
Description
Objective: To assess the efficiency of nandrolone decanoate (ND) in the control of anemia in elderly male patients on hemodialysis (HD), and to determine its influence on nutritional parameters. Design: A prospective 6-month study with randomization of patients on recombinant human erythropoietin (rHuEPO) therapy into two groups. Group A: rHuEPO was stopped before starting treatment with ND. Group E: rHuEPO was continued. Setting: Renal unit, tertiary-care center. Patients: 14 male patients in Group A and 19 patients, 12 males and 7 females, in Group E. Interventions: In Group A rHuEPO was stopped and ND 200 mg/I.M. weekly was given over six months. Results: The increase in hemoglobin and hematocrit levels was progressive with ND, and significant differences (p < 0.003) were evident after six months (9.6 1.0 vs 11.0 1.4 and 28.9 4.7 vs 33.0 4.7, respectively), which remained unmodified in Group E. Group A showed a significant increase in serum creatinine, total protein, transferrin and anthropometric parameters. These parameters remained stable and even presented a tendency to decrease in Group E. There was a significant rise in the concentration of triglycerides and a significant decrease in both HDL-cholesterol and apolipoprotein A-1 in Group A. However, lipoprotein (a) decreased significantly. No significant changes were detected in Group E. Conclusions: The use of ND would allow us an acceptable treatment of anemia as well as a better nutritional condition in elderly male patients on dialysis. Abbreviations: CRF – chronic renal failure; HD – hemodialysis; HDL – high density lipoproteins; LDL – low density lipoproteins; ND – nandrolone decanoate; rHuEPO – recombinant human erythropoietin
Geriatric Nephrology and Urology 9: 67–72, 1999. © 1999 Kluwer Academic Publishers. Printed in the Netherlands. Accepted March 24 1999
