Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Andreas Schulze & Julia Lamparter & Norbert Pfeiffer & Fatmire Berisha & Irene Schmidtmann & Esther M. Hoffmann
- چاپ و سال / کشور: 2011
Description
Purpose To evaluate the diagnostic ability of Fourier-domain optical coherence tomography (FD-OCT) measurements in glaucoma patients, patients with ocular hypertension, and normal subjects. Methods Ninety-three participants with open-angle glaucoma (OAG), 58 patients with ocular hypertension (OHT), and 60 healthy control subjects were included in the study. All study participants underwent FD-OCT imaging. Retinal ganglion cell complex (GCC), macular thickness, peripapillary retinal nerve fiber layer thickness (RFNL), and optic nerve head parameters (ONH) were measured in each participant. The diagnostic ability was evaluated using area under the receiver operating characteristics curves (AUROC). Results Glaucoma patients showed a significant reduction in GCC and macular retinal thickness compared to patients with OHTand normal subjects. No differences in GCC were found between the patients with OHT and normal subjects. The best diagnostic ability in the comparison between glaucoma and normal subjects after adjusting for age was found for cup-todisc ratio (AUROC=0.848), RNFL average thickness (AUROC=0.828), and GCC global loss volume (AUROC= 0.805). The diagnostic power of the best GCC, RNFL, and ONH parameter did not show differences beyond random variation (p>0.05). Conclusions Imaging of the GCC using FD-OCT (RTVue- 100) has a comparable diagnostic ability to RNFL and ONH measurements in distinguishing between glaucoma patients and healthy subjects. No differences were found between patients with OHT and normal subjects with regard to ONH, RNFL, and GCC parameters
Graefes Arch Clin Exp Ophthalmol (2011) 249:1039–1045 DOI 10.1007/s00417-010-1585-5 Received: 6 August 2010 / Revised: 16 November 2010 / Accepted: 18 November 2010 / Published online: 15 January 2011
