Corneal intrastromal tissue modeling with the femtosecond laser
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Christian Meltendorf & Thomas Deller & Hanns Ackermann & Ulrich von Pape
- چاپ و سال / کشور: 2011
Description
Purpose To determine whether central corneal thinning and flattening can be achieved by intrastromal photodisruption using a femtosecond (fs) laser. Setting Institute of Clinical Neuroanatomy, Goethe- University, Frankfurt am Main, Germany. Methods Fourteen horizontal, parallel intrastromal cuts were performed on rabbit eyes using a fs laser. Full-grown rabbits (group 1; ten eyes) received bilateral treatment. Growing rabbits (group 2) received unilateral treatment (four eyes). Slit-lamp examination, pachymetry, and keratometry were performed on day 9, 31 and 86 (group 1) or on day 12, 29, 69, 176 and 318 (group 2) after surgery. Results Nine days after treatment, corneal swelling was present and a slight increase of mean corneal thickness (group 1: +4.40±5.56 ìm) as well as a steeper mean corneal curvature (group 1: .0.18±0.02mm)were observed. In contrast, 1month after tissue photodisruption corneas showed an average decrease of thickness (group 2: .21.0±2.5 ìm). By 6 months post-treatment, a further decrease (group 2: .36.3±6.9 ìm) was seen that remained stable for the rest of the observation period. At 176 days post-treatment, a decrease of corneal curvature (group 2: .0.21±0.10 mm) was found. Slit-lamp examination revealed a transparent cornea. At the site of intrastromal photodisruption a narrow band of increased reflectivity could be detected. Conclusions Corneal thinning can be reliably achieved using intrastromal tissue modeling with a fs laser. Tissue modeling was accompanied by a transient opacity and irregularity of the corneal surface.
Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-011-1701-1 Received: 22 November 2010 / Revised: 7 February 2011 / Accepted: 23 March 2011
