Intravitreal bevacizumab versus photodynamic therapy for myopic choroidal neovascularization in a North-African population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Leila El Matri & Fedra Kort & Ahmed Chebil & Rim Bouraoui & Ahlem Merdassi & Mejda Bouladi
- چاپ و سال / کشور: 2011
Description
Purpose To compare the 1-year functional and anatomical outcomes of intravitreal bevacizumab (IVB) and photodynamic therapy (PDT) in patients with myopic choroidal neovascularization (CNV). Methods Review of retrospectively collected data of 80 eyes in 80 patients with myopic CNV treated with standard PDT (n=40) or IVB (1.25 mg/ 0.05 ml) (n=40). Bestcorrected visual acuity (BCVA) and central retinal thickness (CRT) measured with optical coherence tomography (OCT) were compared between the two groups at baseline, 3, 6 and 12 months. Results In the IVB group, mean BCVA was +0.9±0.85 logMAR at baseline. Mean BCVA was significantly better at 3 and 6 months than baseline (p=.0095 and p=.008, respectively) but not at 12 months (p=.065). In the PDT group, mean BCVA was +0.88±0.45 logMAR at baseline, and improved to +0.85±0.62 logMAR at 3 months and to +0.86±0.44 logMAR at 6 months, which was not significantly different from baseline. Mean BCVA then decreased to +0.9±0.54 logMAR at 12 months (p=.85). Mean logMAR VA was significantly better in the IVB group than in the PDT group after 3 months (p=.0043), 6 months (p=.0001) and 12 months (p=.0168). Mean CRT was significantly lower in IVB group than in PDT group at 3, 6 and 12 months (p=.008, p=.038, p=.040, respectively). Chorioretinal atrophy developed in six eyes (15%) treated with IVB and in 24 eyes (60%) treated with PDT at 12 months (p=3.2×10-5). Conclusions Over a 12-month period, intravitreal bevacizumab seems to be superior to photodynamic therapy in controlling myopic CNV in a North-African population
Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-011-1654-4 Received: 1 September 2010 / Revised: 4 January 2011 / Accepted: 7 February 2011
