Multidetector computed tomography evaluation of coronary plaque morphology in patients with stable angina
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daisuke Utsunomiya Takashi Fukunaga Seitaro Oda Kazuo Awai Takeshi Nakaura Joji Urata Yasuyuki Yamashita
- چاپ و سال / کشور: 2010
Description
The purpose of this study was to evaluate the morphology and composition of atherosclerotic coronary plaques in patients with stable coronary artery disease by 64-row multidetector computed tomography (CT) angiography. Atotal of 56 patientswere divided into an ischemia-related (n = 31) and a nonischemia-related lesion group (n = 25) based on myocardial perfusion scintigraphy, invasive angiography, and 1-year clinical follow-up. The 56 lesions detected by CT imaging were analyzed; the severity of stenosis, the lesion length, CT attenuation value, and calcium deposition of the plaques were evaluated. Clinical characteristics andCTfindings were compared using univariate and multivariate logistic regression analyses. Ischemia-related lesions exhibited a greater severity of coronary stenosis, were longer (17.8 ± 8.5 vs 9.1 ± 3.9 mm), and had a higher CT attenuation value (101.7 ± 36.7 vs 81.6 ± 32.6 HU) and larger calcium deposition. By univariate logistic analysis, severity of stenosis, lesion length, CT attenuation value, and calcium deposition were significantly associated with ischemia-related plaques. The odds ratio (OR) of these parameters was 6.874 (P = 0.007), 1.371 (P = 0.001), 1.018 (P = 0.044), and 5.400 (P = 0.004), respectively. By multivariate logistic analysis, the severity of stenosis and lesion length were significantly associated with ischemiarelated plaques (OR 7.588, P = 0.036 and OR 1.365, P = 0.003, respectively). In conclusion, coronary CT angiography is useful for the identification of morphological differences between ischemia-related and nonischemiarelated plaques in patients with stable coronary artery disease.
Heart Vessels (2011) 26:392–398 DOI 10.1007/s00380-010-0074-4 Received: 1 March 2010 / Accepted: 16 July 2010 / Published online: 4 December 2010
