Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Rainer Pirzer Elif Elmas Dariusch Haghi Christiane Lippert Stefan Kralev Siegfried Lang Martin Borggrefe Thorsten Ka¨lsch
- چاپ و سال / کشور: 2011
Description
Patients with Takotsubo cardiomyopathy (TC) often present with symptoms similar to those of myocardial infarction (MI). We analyzed blood concentrations of mediators of inflammation and platelet- and monocyteactivity markers in patients with TC and MI for significant differences. Clinical data of patients with TC (n = 16) and acute MI (n = 16) were obtained. Serial blood samples were taken at the time of hospital admission (t0), after 2–4 days (t1) and after 4–7 weeks (t2), respectively. Plasma concentrations of interleukin (IL)-6, IL-7, soluble CD40 ligand (sCD40L), and monocyte chemotactic protein 1 (MCP-1) were determined with an ELISA. Tissue factor binding on monocytes, platelet-activation marker CD62P, platelet CD40-ligand (CD40L), and platelet-monocyte aggregates were measured using flow cytometry. Expression of CD62P on platelets and IL-6 plasma levels were significantly lower in patients with TC compared to MI at the time of hospital admission. IL-7 plasma levels were significantly elevated in patients with TC compared to patients with MI at 2–4 days after hospital admission. No significant differences were observed concerning sCD40L and MCP-1 plasma levels, tissue factor binding on monocytes, CD40L expression on platelets, and platelet-monocyte aggregates at any point in time. Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of MI and TC.
Heart Vessels DOI 10.1007/s00380-011-0132-6 Received: 14 November 2010 / Accepted: 25 February 2011
