Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kan Dong Jun-Hua Ge Shu-Lian Gu Shan Li Wei-Guo Zhu Fang-Yan Fan Jian-Hua Zhu
- چاپ و سال / کشور: 2010
Description
The importance of the interaction between natural killer (NK) cells and dendritic cells (DCs) in the expansion of antiviral and antitumor immune responses is well documented; however, limited information on NK/DC interaction during atherosclerosis is available. Inflammation plays an important role in the development of atherosclerosis, and oxidized low-density lipoprotein (ox-LDL) is believed to play a critical role in the development and progression of atherosclerosis. In this study, we developed a NK/DC coculture system to examine the role of ox-LDL in modulating the interaction of mice NK cells and DCs. Fresh NK cells were cocultured with DCs in the absence or presence of ox-LDL.We examined the cytokines released during the interaction. This report provides the first evidence of an enhancement effect by ox-LDL on the NK/DC crosstalk. Notably, we found that ox-LDL significantly promoted the interaction of NK cells and DCs via CD48-2B4 contactdependent mechanisms. These findings highlight the importance of NK/DCs crosstalk in atherosclerosis and provide new information about the possible mechanisms of atherosclerosis.
Heart Vessels DOI 10.1007/s00380-010-0102-4 Received: 23 May 2010 / Accepted: 5 November 2010
