Flavanol-rich cocoa ameliorates lipemia-induced endothelial dysfunction
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sabine Westphal Claus Luley
- چاپ و سال / کشور: 2010
Description
Consumption of flavanols improves chronic endothelial dysfunction. We investigated whether it can also improve acute lipemia-induced endothelial dysfunction. In this randomized, placebo-controlled, double-blind, crossover trial, 18 healthy subjects received a fatty meal with cocoa either rich in flavanols (918 mg) or flavanolpoor. Flow-mediated dilation (FMD), triglycerides, and free fatty acids were then determined over 6 h. After the flavanol-poor fat loading, the FMD deteriorated over 4 h. The consumption of flavanol-rich cocoa, in contrast, improved this deterioration in hours 2, 3, and 4 without abolishing it completely. Flavanols did not have any influence on triglycerides or on free fatty acids. Flavanolrich cocoa can alleviate the lipemia-induced endothelial dysfunction, probably through an improvement in endothelial NO synthase.
Heart Vessels DOI 10.1007/s00380-010-0085-1 Received: 21 April 2009 / Accepted: 3 September 2010
