Evidence for impaired vagus nerve activity in heart failure
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Steve Bibevski Mark E. Dunlap
- چاپ و سال / کشور: 2010
Description
Parasympathetic control of the heart via the vagus nerve is the primary mechanism that regulates beatto- beat control of heart rate. Additionally, the vagus nerve exerts significant effects at the AV node, as well as effects on both atrial and ventricular myocardium. Vagal control is abnormal in heart failure, occurring at early stages of left ventricular dysfunction, and this reduced vagal function is associated with worse outcomes in patients following myocardial infarction and with heart failure. While central control mechanisms are abnormal, one of the primary sites of attenuated vagal control is at the level of the parasympathetic ganglion. It remains to be seen whether or not preventing or treating abnormal vagal control of the heart improves prognosis.
Heart Fail Rev (2011) 16:129–135 DOI 10.1007/s10741-010-9190-6 Published online: 5 September 2010
