Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gerjon Hannink • Tony G. van Tienen • Arend Jan Schouten • Pieter Buma
- چاپ و سال / کشور: 2010
Description
Purpose To evaluate the long-term effects of implantation of a biodegradable polymer meniscus implant on articular cartilage degeneration and compare this to articular cartilage degeneration after meniscectomy. Methods Porous polymer polycaprolacton-based polyurethane meniscus implants were implanted for 6 or 24 months in the lateral compartment of Beagle dog knees. Contralateral knees were meniscectomized, or left intact and served as controls. Articular cartilage degeneration was evaluated in detail using India ink staining, routine histology, immunochemistry for denatured (Col2-M) and cleaved (Col2-Cshort) type II collagen, Mankin’s grading system, and cartilage thickness measurements. Results Histologically, fibrillation and substantial immunohistochemical staining for both denatured and cleaved type II collagen were found in all three treatment groups. The cartilage of the three groups showed identical degradation patterns. In the 24 months implant group, degradation appeared to be more severe when compared to the 6 months implant group and meniscectomy group. Significantly more cartilage damage (India ink staining, Mankin’s grading system, and cartilage thickness measurements) was found in the 24 months implant group compared to the 6 months implant group and meniscectomy group. Conclusion Degradation of the cartilage matrix was the result of both mechanical overloading as well as localized cell-mediated degradation. The degeneration patterns were highly variable between animals. Clinical application of a porous polymer implant for total meniscus replacement is not supported by this study.
Knee Surg Sports Traumatol Arthrosc (2011) 19:441–451 DOI 10.1007/s00167-010-1244-8 Received: 9 February 2010 / Accepted: 2 August 2010 / Published online: 28 August 2010
