Analysis of sequential cytokine release after ACL reconstruction
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : A. L. Hayward • D. J. Deehan • R. M. Aspden • A. G. Sutherland
- چاپ و سال / کشور: 2011
Description
Purpose Rupture of the anterior cruciate ligament is common and may necessitate surgical reconstruction. Surgical reconstruction aims to restore normal kinematics and biology within the knee. The acute phase response after surgical reconstruction remains poorly defined but may influence graft integration through modulation of host tissue remodelling. Methods The very early host production of key cytokines after surgery was studied. A consecutive series of 14 patients undergoing reconstructive surgery were studied per-operatively, 1 and 6 h after surgery, examining the hypothesis that the acute phase response would be nonspecific but consistent between individuals, demonstrating increases of pro-inflammatory cytokines. Results A consistent increased release of monocyte-driven, non-specific, IL-1 and IL-6 release but not T cell-derived IL-2 was found. Perhaps, more interestingly, very early high concentrations of secondary growth factors PDGF and TGF-b suggestive of an anabolic response were found. Conclusion These data support the contention that an anabolic response starts earlier than previously thought within the surgically reconstructed knee
Knee Surg Sports Traumatol Arthrosc DOI 10.1007/s00167-011-1486-0 Received: 10 October 2010 / Accepted: 15 March 2011
