Effect of laser on TNF-alpha expression in inflamed human gingival tissue
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Snezana Pesevska & Marija Nakova & Icko Gjorgoski & Nikola Angelov & Kiro Ivanovski & Salvador Nares & Sebastiano Andreana
- چاپ و سال / کشور: 2011
Description
This study sought to evaluate the effect of lowlevel laser treatment combined with scaling and root planing (SRP) on gingival tissue levels of TNF-alpha in subjects with periodontal disease. Eighty gingival papilla biopsy samples were obtained from 60 patients diagnosed with chronic advanced periodontitis; randomly assigned to three treatment groups (n=20), as well as 20 subjects with no periodontal disease (group A). Group B received SRP on a single quadrant/day for four consecutive days. On day 5, all quadrants were rescaled. Groups C and D received the same treatment as group B plus laser application with the low-level diode laser (630–670 nm, 1.875 J/cm2) for five and ten consecutive days, respectively. Papilla biopsies were obtained from subjects and evaluated by ELISA for levels of TNF-alpha. The values in the control group were 5.2±3.21 pg/mg and baseline values for the examined groups were 46.01±16.69. Significantly decreased level of TNF-alpha for groups C and D was found after treatment, while group B demonstrated reduction of TNF-alpha of 31.34%. The results of this study show suppression of TNF-alpha in gingival tissue after low-level laser treatment as adjunct to SRP. Data may suggest beneficial antiinflammatory effects of the laser treatment when used as adjunctive periodontal treatment.
Lasers Med Sci DOI 10.1007/s10103-011-0898-x Received: 8 April 2010 / Accepted: 14 February 2011
