Quantitative assessment of trabecular bone micro-architecture of the wrist via 7Tesla MRI: preliminary results
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gregory Chang · Ligong Wang · Guoyuan Liang · James S. Babb · Graham C. Wiggins · Punam K. Saha · Ravinder R. Regatte
- چاپ و سال / کشور: 2011
Description
Object The goal of this studywas to determine the feasibility of performing quantitative 7T magnetic resonance imaging (MRI) assessment of trabecular bone micro-architecture of the wrist, a common fracture site. Materials and methods The wrists of 4 healthy subjects (1woman, 3men, 28پ}8.9 years) were scanned on a 7Twhole body MR scanner using a 3D fast low-angle shot (FLASH) sequence (TR/TE=20/4.5ms, 0.169پ~0.169پ~0.5mm).Trabecular bone was segmented and divided into 4 or 8 angular subregions. Total bone volume (TBV), bone volume fraction (BVF), surface-curve ratio (SC), and erosion index (EI) were computed. Subjects were scanned twice to assess measurement reproducibility. Results Group mean subregional values for TBV, BVF, SC, and EI (8 subregion analysis) were as follows: 8489 پ} 3686, 0.27 پ} 0.045, 9.61 پ} 6.52; and 1.43 پ} 1.25. Within each individual, there was subregional variation in TBV, SC, and EI (>5%), but not BVF (<5%). Intersubject variation (.12%) existed for all parameters. Within-subject coefficients of variation were .10%. Conclusion This is the first study to perform quantitative 7T MRI assessment of trabecular bone micro-architecture of the wrist. This method could be utilized to study perturbations in bone structure in subjects with osteoporosis or other bone disorders.
Magn Reson Mater Phy (2011) 24:191–199 DOI 10.1007/s10334-011-0252-0 Received: 27 December 2010 / Revised: 4 April 2011 / Accepted: 5 April 2011 / Published online: 5 May 2011
